Research

Product Profile and Pipeline | Publications | Research Collaborations


LifeSensors’s Research and Development Team is dedicated to developing technologies for difficult-to-express proteins and the ubiquitin Drug Discovery platform. In addition to the systems marketed on our website, we are constantly improving and developing new expression systems for E.coli, yeast, Pichia pastoris, and insect and mammalian cells. Currently our team is developing novel tags that enhance expression, induce cleavage that generates native structure, and aid in the purification of fusion proteins. Our novel tag is superior to nickel affinity chromatography for protein purification, and yet it is cost effective. Currently, our R&D Team is actively engaged in integrating LifeSensors’s protein expression platform into the production of therapeutic proteins.

Drug Discovery and Research Tools for Ubiquitin and UBL Pathway
LifeSensors has in place a dedicated team of biochemists and medicinal chemists engaged in development of tools to advance the science of ubiquitin and ubiquitin-like proteins (UBL). Its scientists have expressed and purified a number of de-ubiquitylases (DUBs) and ubiquitin ligases. LifeSensors leads the industry in developing the most novel assays for research and drug discovery, including multiplex assays for HTS.

LifeSensors produces the highest quality reagents and kits to assay DUBs and ligases in the industry. Many of these novel assays are proprietary technology developed at LifeSensors or licensed from the patent owners in industry or academia.

Functional DUB Production and Testing
UBs are very difficult to express. Nevertheless, LifeSensors has been able to express many functionally active DUBs using its proprietary technology. Its protocols for producing functional deubiquitinating enzymes for use in drug screening, cell biology, and therapeutic applications are well-known (see DUB Array below). In addition to the DUBs listed in our catalogue, numerous other functional DUBs are currently being generated and tested. Please contact us for additional information.

Antibody Generation
LifeSensors is currently involved in several collaborations to develop the highest quality antibodies for studying ubiquitin-like proteins, SUMO, and deubiquitinating enzymes. We are developing ubiquitin, SUMO, and deubiquitylase antibodies that will soon be available in our product catalogue for online ordering.

Assay Development
Our chemistry department is currently developing novel active protease arrays based on a proprietary chemical platform for use in early diagnosis of cancer and neurodegenerative diseases. Please contact us for additional information and possible collaboration.